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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:64163
Term: diquat
Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Chemical ID: MESH:D004178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2increases activityEXP 6480464CTDDiquat results in increased activity of NFE2L2 proteinPMID:20143881 PMID:21172416
NFE2L2decreases expressionISONfe2l2 (Mus musculus)6480464CTDDiquat results in decreased expression of NFE2L2 mRNA; Diquat results in decreased expression of NFE2L2 proteinPMID:33475796 PMID:35268077 PMID:36572071
NFE2L2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 results in decreased susceptibility to DiquatPMID:23056183
NFE2L2increases activityISONfe2l2 (Mus musculus)6480464CTDDiquat results in increased activity of NFE2L2 proteinPMID:16962985
NFE2L2increases expressionISONfe2l2 (Mus musculus)6480464CTDDiquat results in increased expression of NFE2L2 proteinPMID:20826540
NFE2L2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to DiquatPMID:16962985 PMID:22762311
NFE2L2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Ellagic Acid co-treated with Diquat] results in increased expression of NFE2L2 mRNA; Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 protein]; Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]PMID:20826540 PMID:22762311 PMID:33475796 PMID:35268077
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