Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2decreases methylationEXP 6480464CTDfumonisin B1 results in decreased methylation of NFE2L2 promoterPMID:33496827
NFE2L2increases expressionEXP 6480464CTDfumonisin B1 results in increased expression of NFE2L2 mRNA; fumonisin B1 results in increased expression of NFE2L2 proteinPMID:33496827
NFE2L2increases methylationEXP 6480464CTDfumonisin B1 results in increased methylation of NFE2L2 mRNAPMID:33496827
NFE2L2multiple interactionsEXP 6480464CTD[fumonisin B1 results in decreased expression of MIR27B mRNA] which results in increased expression of NFE2L2 mRNA; [fumonisin B1 results in decreased expression of MIR27B mRNA] which results in increased expression of NFE2L2 protein; [fumonisin B1 results in decreased methylation of NFE2L2 promoter] which results in increased expression of NFE2L2 mRNA; MIR27B mRNA inhibits the reaction [fumonisin B1 results in increased expression of NFE2L2 mRNA]; MIR27B mRNA inhibits the reaction [fumonisin B1 results in increased expression of NFE2L2 protein]PMID:33496827
NFE2L2affects expressionISONfe2l2 (Mus musculus)6480464CTDfumonisin B1 affects the expression of NFE2L2 mRNAPMID:35697133
NFE2L2increases expressionISONfe2l2 (Mus musculus)6480464CTDfumonisin B1 results in increased expression of NFE2L2 mRNAPMID:16221962
Go Back to source page   Continue to Ontology report