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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNincreases activityISOJun (Rattus norvegicus)6480464CTDsulforaphane results in increased activity of JUN proteinPMID:20237067
JUNincreases expressionISOJun (Rattus norvegicus)6480464CTDsulforaphane results in increased expression of JUN proteinPMID:20237067
JUNmultiple interactionsISOJun (Rattus norvegicus)6480464CTD[sulforaphane promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; sulforaphane promotes the reaction [JUN protein binds to GSTP1 enhancer]PMID:20237067
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