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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:30956
Term: trichloroacetic acid
Definition: A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
Chemical ID: MESH:D014238
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNdecreases methylationISOJun (Mus musculus)6480464CTDTrichloroacetic Acid results in decreased methylation of JUN promoterPMID:10774822
JUNincreases expressionISOJun (Mus musculus)6480464CTDTrichloroacetic Acid results in increased expression of JUN proteinPMID:10774822
JUNmultiple interactionsISOJun (Mus musculus)6480464CTD[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of JUN protein]PMID:10774822
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