GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | JUN | affects expression | EXP | | 6480464 | CTD | Doxorubicin affects the expression of JUN mRNA | PMID:15205334 | JUN | affects response to substance | EXP | | 6480464 | CTD | JUN protein affects the susceptibility to Doxorubicin | PMID:18645001 | JUN | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of JUN protein | PMID:15585644 | JUN | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of JUN protein | PMID:15585644 | JUN | multiple interactions | EXP | | 6480464 | CTD | [Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein; Doxorubicin promotes the reaction [JUN protein binds to ABCC1 promoter]; Doxorubicin promotes the reaction [JUN protein binds to ESR1 promoter]; Doxorubicin promotes the reaction [TP53 protein binds to JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein] | PMID:15880572 PMID:19351845 PMID:21911303 | JUN | increases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of JUN mRNA | PMID:16243910 PMID:22712078 | JUN | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA] | PMID:22712078 | | ||||||||||||||||||||||
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