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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27789
Term: 1,2-dichloroethane
Definition: A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.
Chemical ID: MESH:C024565
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNincreases expressionISOJun (Mus musculus)6480464CTDethylene dichloride results in increased expression of JUN mRNA; ethylene dichloride results in increased expression of JUN proteinPMID:28189721 PMID:28960355 PMID:30081051
JUNmultiple interactionsISOJun (Mus musculus)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ethylene dichloride results in increased expression of JUN protein]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with ethylene dichloride] results in decreased expression of JUN proteinPMID:30081051
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