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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNmultiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of JUN mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of JUN mRNA; [Air Pollutants results in increased abundance of Ozone] which affects the expression of JUN mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of JUN mRNAPMID:32699268 PMID:35430440
JUNincreases activityISOJun (Mus musculus)6480464CTDOzone results in increased activity of JUN protein modified formPMID:21543283
JUNincreases expressionISOJun (Mus musculus)6480464CTDOzone results in increased expression of JUN mRNAPMID:16864405
JUNincreases expressionISOJun (Rattus norvegicus)6480464CTDOzone results in increased expression of JUN mRNAPMID:16330353
JUNincreases phosphorylationISOJun (Mus musculus)6480464CTDOzone results in increased phosphorylation of JUN proteinPMID:17460151
JUNmultiple interactionsISOJun (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of JUN mRNA; [Lipopolysaccharides co-treated with Ozone] results in increased expression of JUN mRNA; pyrazolanthrone inhibits the reaction [Ozone results in increased phosphorylation of JUN protein]PMID:16864405 PMID:17460151 PMID:34911549
JUNmultiple interactionsISOJun (Rattus norvegicus)6480464CTD[[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] affects the expression of JUN mRNA; [Ozone co-treated with Chlorine] affects the expression of JUN mRNAPMID:18636392 PMID:37088303
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