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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNaffects localizationEXP 6480464CTDQuercetin affects the localization of JUN proteinPMID:20804812 PMID:21165570
JUNdecreases activityEXP 6480464CTDQuercetin results in decreased activity of JUN proteinPMID:20804812
JUNdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of JUN mRNA; Quercetin results in decreased expression of JUN protein modified formPMID:27041924 PMID:38134066
JUNincreases expressionEXP 6480464CTDQuercetin results in increased expression of JUN mRNAPMID:21632981
JUNincreases phosphorylationEXP 6480464CTDQuercetin results in increased phosphorylation of JUN proteinPMID:14688022
JUNmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin affects the localization of JUN protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased phosphorylation of JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [AR protein binds to JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]; [Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Quercetin affects the localization of JUN protein]; Quercetin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; Quercetin promotes the reaction [JUN protein binds to CYP1A2 enhancer]; Quercetin results in decreased expression of and results in decreased phosphorylation of JUN protein; U 0126 inhibits the reaction [Quercetin results in increased phosphorylation of JUN protein]PMID:10484327 PMID:10620351 PMID:14688022 PMID:15795422 PMID:17458902 PMID:18341430 PMID:18628248 PMID:18982426 PMID:20148354 PMID:21165570 PMID:21308698 PMID:23645742
JUNmultiple interactionsISOJun (Mus musculus)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased activity of JUN protein]PMID:11543732
JUNmultiple interactionsISOJun (Rattus norvegicus)6480464CTDPPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of JUN protein]]; Quercetin inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of JUN protein]; Quercetin inhibits the reaction [Glucose affects the localization of JUN protein]PMID:20542118 PMID:24039778 PMID:9890986
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