GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2l11 | increases cleavage | ISO | BCL2L11 (Homo sapiens) | 6480464 | CTD | methylselenic acid results in increased cleavage of BCL2L11 protein | PMID:18790785 | Bcl2l11 | increases expression | ISO | BCL2L11 (Homo sapiens) | 6480464 | CTD | methylselenic acid results in increased expression of BCL2L11 mRNA; methylselenic acid results in increased expression of BCL2L11 protein | PMID:17339365 PMID:28161410 | Bcl2l11 | multiple interactions | ISO | BCL2L11 (Homo sapiens) | 6480464 | CTD | BCL2L11 protein affects the susceptibility to [Doxorubicin co-treated with methylselenic acid]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of BCL2L11 protein] | PMID:17339365 PMID:18790785 | | ||||||||||||||||||||||
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