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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734300
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2l11
Name: BCL2 like 11
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11increases activityISOBCL2L11 (Homo sapiens)6480464CTDBortezomib results in increased activity of BCL2L11 proteinPMID:16446371
Bcl2l11increases expressionISOBCL2L11 (Homo sapiens)6480464CTDBortezomib results in increased expression of BCL2L11 proteinPMID:16024631 PMID:17326159 PMID:18566236
Bcl2l11increases response to substanceISOBCL2L11 (Homo sapiens)6480464CTDBCL2L11 results in increased susceptibility to BortezomibPMID:18566236
Bcl2l11multiple interactionsISOBCL2L11 (Homo sapiens)6480464CTD[Bortezomib co-treated with romidepsin] results in increased expression of BCL2L11 protein; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased expression of BCL2L11 protein]; Bortezomib inhibits the reaction [Arsenic Trioxide results in increased degradation of BCL2L11 protein]PMID:15173094 PMID:36509116
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