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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734299
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L11
Name: BCL2 like 11
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L11increases expressionEXP 6480464CTDDexamethasone results in increased expression of BCL2L11 mRNAPMID:12782123
BCL2L11increases phosphorylationEXP 6480464CTDDexamethasone results in increased phosphorylation of BCL2L11 proteinPMID:20067466
BCL2L11increases response to substanceEXP 6480464CTDBCL2L11 protein results in increased susceptibility to DexamethasonePMID:14996839
BCL2L11multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL2L11 mRNA; GSTM1 protein inhibits the reaction [Dexamethasone results in increased phosphorylation of BCL2L11 protein]; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of BCL2L11 protein]PMID:18515658 PMID:20067466 PMID:28628672
BCL2L11increases expressionISOBcl2l11 (Mus musculus)6480464CTDDexamethasone results in increased expression of BCL2L11 mRNA alternative form; Dexamethasone results in increased expression of BCL2L11 proteinPMID:14996839 PMID:17953376
BCL2L11increases response to substanceISOBcl2l11 (Mus musculus)6480464CTDBCL2L11 protein results in increased susceptibility to DexamethasonePMID:14996839
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