Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	734247
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Tnfrsf1a
Name:	tumor necrosis factor receptor superfamily, member 1a

Acc ID:	CHEBI:25812
Term:	ozone
Definition:	An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID:	MESH:D010126

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnfrsf1a	affects expression	EXP		6480464	CTD	Ozone affects the expression of TNFRSF1A mRNA	PMID:11159038
Tnfrsf1a	increases expression	EXP		6480464	CTD	Ozone results in increased expression of TNFRSF1A protein	PMID:15516495 PMID:16002559 PMID:17575079
Tnfrsf1a	multiple interactions	EXP		6480464	CTD	IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein]; IL6 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of CCL2 protein]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of CXCL1 protein]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of CXCL10 protein]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of CXCL2 protein]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of IL6 protein]; TNFRSF1A protein affects the reaction [Ozone affects the expression of TNFRSF1B mRNA]; TNFRSF1B protein affects the reaction [Ozone affects the expression of TNFRSF1A mRNA]	PMID:11159038 PMID:15516495 PMID:17575079 PMID:22066571
Tnfrsf1a	increases expression	ISO	TNFRSF1A (Homo sapiens)	6480464	CTD	Ozone results in increased expression of TNFRSF1A mRNA	PMID:27206323
Tnfrsf1a	multiple interactions	ISO	TNFRSF1A (Homo sapiens)	6480464	CTD	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TNFRSF1A mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TNFRSF1A mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of TNFRSF1A mRNA	PMID:32699268

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