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GENE - TERM ANNOTATION REPORT

RGD ID: 734195
Species: Homo sapiens
RGD Object: Gene
Symbol: CHRM3
Name: cholinergic receptor muscarinic 3
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRM3is_active_inIBAMGI:88396 or MGI:88397 or PANTHER:PTN001207082 or Chrm1 (Rattus norvegicus) or Chrm3 (Rattus norvegicus) or Chrm4 (Rattus norvegicus) or Chrm2 (Rattus norvegicus) or UniProtKB:A0A5F7ZKY2 or WB:WBGene00001517150520179GO_Central GO_REF:0000033
CHRM3located_inIEAGO:0007213 or GO:0095500150520179GOC GO_REF:0000108
CHRM3located_inIEAPANTHER:PTHR24247:SF183150520179TreeGrafter GO_REF:0000118
CHRM3located_inIEAUniProtKB-KW:KW-0770150520179UniProt GO_REF:0000043
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