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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734192
Species: Mus musculus
RGD Object: Gene
Symbol: Gpt
Name: glutamic pyruvic transaminase, soluble
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDtert-Butylhydroperoxide results in increased activity of GPT proteinPMID:28025122
Gptmultiple interactionsEXP 6480464CTDrutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]PMID:28025122
Gptincreases activityISOGpt (Rattus norvegicus)6480464CTDtert-Butylhydroperoxide results in increased activity of GPT proteinPMID:15212457 PMID:15645217
Gptincreases expressionISOGpt (Rattus norvegicus)6480464CTDtert-Butylhydroperoxide results in increased expression of GPT proteinPMID:15015760 PMID:15095147
Gptmultiple interactionsISOGpt (Rattus norvegicus)6480464CTDbaicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]; caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of GPT protein]PMID:15095147 PMID:15212457 PMID:15645217
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