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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734192
Species: Mus musculus
RGD Object: Gene
Symbol: Gpt
Name: glutamic pyruvic transaminase, soluble
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDDiclofenac results in increased activity of GPT proteinPMID:26934552
Gptincreases expressionEXP 6480464CTDDiclofenac results in increased expression of GPT proteinPMID:24747151 PMID:27671914
Gptmultiple interactionsEXP 6480464CTDeritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]PMID:24747151
Gptincreases expressionISOGpt (Rattus norvegicus)6480464CTDDiclofenac results in increased expression of GPT proteinPMID:30925002
Gptincreases secretionISOGPT (Homo sapiens)6480464CTDDiclofenac results in increased secretion of GPT proteinPMID:36442613
Gptmultiple interactionsISOGpt (Rattus norvegicus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]PMID:23939143 PMID:31813902
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