GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gpt | increases abundance | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased abundance of GPT protein | PMID:36113623 | Gpt | increases activity | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased activity of GPT protein | PMID:27836789 PMID:29859236 PMID:36037915 | Gpt | increases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased expression of GPT protein | PMID:33290806 PMID:36442531 | Gpt | multiple interactions | EXP | | 6480464 | CTD | [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]; eumelanin inhibits the reaction [Diethylnitrosamine results in increased abundance of GPT protein]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; mitoquinone inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]]; SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]; Sorafenib inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Vitamin D inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein] | PMID:27836789 PMID:29859236 PMID:33290806 PMID:36037915 PMID:36113623 PMID:36442531 PMID:37436232 | Gpt | decreases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of GPT mRNA | PMID:19041683 | Gpt | increases activity | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased activity of GPT protein | PMID:17034775 PMID:28804948 PMID:30779474 PMID:30920066 | Gpt | increases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of GPT protein | PMID:24954034 PMID:27565560 PMID:29698782 PMID:31129132 PMID:32302048 PMID:35437842 | Gpt | multiple interactions | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | 1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPT mRNA; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased activity of GPT protein; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GPT protein; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [Diethylnitrosamine results in increased activity of GPT protein]; citral inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; Diethylnitrosamine promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of GPT protein]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; formylchromone analog inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased activity of GPT protein]; piperlongumine inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GPT protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein] | PMID:17034775 PMID:18164116 PMID:24954034 PMID:28414157 PMID:28693887 PMID:29923357 PMID:30779474 PMID:30920066 PMID:31129132 PMID:32302048 PMID:35113675 PMID:35437842 | | ||||||||||||||||||||||
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