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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734192
Species: Mus musculus
RGD Object: Gene
Symbol: Gpt
Name: glutamic pyruvic transaminase, soluble
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDDoxorubicin results in increased activity of GPT proteinPMID:25680506
Gptincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of GPT proteinPMID:36811345 PMID:37409694
Gptmultiple interactionsEXP 6480464CTD[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein; BDKRB1 protein affects the reaction [Doxorubicin results in increased expression of GPT protein]; BDKRB2 protein affects the reaction [Doxorubicin results in increased expression of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]; Silymarin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]PMID:29481770 PMID:36811345 PMID:37409694
Gptincreases activityISOGpt (Rattus norvegicus)6480464CTDDoxorubicin results in increased activity of GPT proteinPMID:31100273 PMID:31830546 PMID:34343525
Gptmultiple interactionsISOGpt (Rattus norvegicus)6480464CTDchloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]; Doxorubicin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; geraniol inhibits the reaction [Doxorubicin results in increased activity of GPT protein]; morin inhibits the reaction [Doxorubicin results in increased activity of GPT protein]PMID:29133031 PMID:31100273 PMID:34343525
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