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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734188
Species: Homo sapiens
RGD Object: Gene
Symbol: PTPN6
Name: protein tyrosine phosphatase non-receptor type 6
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTPN6decreases methylationEXP 6480464CTDArsenic Trioxide results in decreased methylation of PTPN6 promoterPMID:19950550
PTPN6increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of PTPN6 mRNA; Arsenic Trioxide results in increased expression of PTPN6 proteinPMID:19950550 PMID:23815908 PMID:24762999 PMID:29409467 PMID:29633893
PTPN6multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Decitabine] results in increased expression of PTPN6 mRNA; Arsenic Trioxide results in decreased methylation of and results in increased expression of PTPN6; pervanadate inhibits the reaction [Arsenic Trioxide results in increased expression of PTPN6 protein]; PTPN6 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of JAK2 protein]; PTPN6 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of STAT3 protein]PMID:19619438 PMID:24762999 PMID:29409467
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