GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptger2 | increases activity | EXP | | 6480464 | CTD | Dinoprostone results in increased activity of PTGER2 protein | PMID:15930264 | Ptger2 | increases activity | ISO | PTGER2 (Homo sapiens) | 6480464 | CTD | Dinoprostone results in increased activity of PTGER2 protein | PMID:23526216 | Ptger2 | increases expression | ISO | PTGER2 (Homo sapiens) | 6480464 | CTD | Dinoprostone results in increased expression of PTGER2 protein | PMID:17709599 PMID:30208247 | Ptger2 | multiple interactions | ISO | PTGER2 (Homo sapiens) | 6480464 | CTD | [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein]; Dinoprostone binds to and results in increased activity of PTGER2 protein; Dinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER2 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]; PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein] | PMID:15131310 PMID:17761898 PMID:23526216 PMID:27636113 PMID:30102254 PMID:30208247 | Ptger2 | multiple interactions | ISO | Ptger2 (Rattus norvegicus) | 6480464 | CTD | PTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein] | PMID:17408863 | | ||||||||||||||||||||||
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