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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734157
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Acc ID: CHEBI:50730
Term: montelukast
Definition: An aliphatic sulfide that has formula 586.18398.
Chemical ID: MESH:C093875
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c29decreases activityISOCYP2C8 (Homo sapiens)6480464CTDmontelukast results in decreased activity of CYP2C8 proteinPMID:15601807 PMID:17994679 PMID:19328226 PMID:21336516 PMID:33253783 PMID:33775687
Cyp2c29increases metabolic processingISOCYP2C8 (Homo sapiens)6480464CTDCYP2C8 protein results in increased metabolism of montelukastPMID:19309152
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