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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734157
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c29decreases activityEXP 6480464CTDQuercetin results in decreased activity of CYP2C29 proteinPMID:18420780
Cyp2c29decreases activityISOCYP2C8 (Homo sapiens)6480464CTDQuercetin results in decreased activity of CYP2C8 proteinPMID:15155557 PMID:15601807 PMID:29689254
Cyp2c29multiple interactionsISOCYP2C8 (Homo sapiens)6480464CTD[Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]; Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Quercetin inhibits the reaction [CYP2C8 protein results in increased metabolism of auriculasin]PMID:11502731 PMID:12967198 PMID:24120545 PMID:31515991
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