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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734104
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4increases expressionISONr1h4 (Rattus norvegicus)1625201RGDobeticholic acid increases expression of Nr1H4 mRNA in rat hepatic stellate cells; obeticholic acid increases expression of Nr1h4 mRNA in bile duct ligation and porcine serum induced models of cirrhosis in rat 
Nr1h4multiple interactionsISONr1h4 (Rattus norvegicus)15036816RGDObeticholic acid inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine] 
Nr1h4increases activityEXP 6480464CTDobeticholic acid results in increased activity of NR1H4 proteinPMID:35688268
Nr1h4increases expressionEXP 6480464CTDobeticholic acid results in increased expression of NR1H4 proteinPMID:27865854
Nr1h4increases response to substanceEXP 6480464CTDNR1H4 protein results in increased susceptibility to obeticholic acidPMID:21242261
Nr1h4multiple interactionsEXP 6480464CTD[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 protein; NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein]PMID:22135065 PMID:22918042 PMID:29660435 PMID:35688268 PMID:36328986 PMID:36787806
Nr1h4increases activityISONR1H4 (Homo sapiens)6480464CTDobeticholic acid results in increased activity of NR1H4 proteinPMID:15911693 PMID:17567710 PMID:27871908
Nr1h4increases expressionISONr1h4 (Rattus norvegicus)6480464CTDobeticholic acid results in increased expression of NR1H4 mRNAPMID:15860571 PMID:15980055 PMID:27255380
Nr1h4multiple interactionsISONr1h4 (Rattus norvegicus)6480464CTDobeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]PMID:22918042 PMID:27255380 PMID:32673658
Nr1h4multiple interactionsISONR1H4 (Homo sapiens)6480464CTDobeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]PMID:15911693 PMID:22918042 PMID:28887089 PMID:29660435
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