GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | decreases expression | EXP | | 6480464 | CTD | Lithocholic Acid results in decreased expression of NR1H4 mRNA | PMID:20359477 | Nr1h4 | increases activity | EXP | | 6480464 | CTD | Lithocholic Acid results in increased activity of NR1H4 protein | PMID:22531947 | Nr1h4 | increases response to substance | EXP | | 6480464 | CTD | NR1H4 protein results in increased susceptibility to Lithocholic Acid; NR1H4 results in increased susceptibility to Lithocholic Acid | PMID:12875239 PMID:21480330 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]] | PMID:19196849 PMID:21480330 PMID:22531947 | Nr1h4 | decreases expression | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in decreased expression of NR1H4 mRNA | PMID:20888898 | Nr1h4 | increases activity | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Lithocholic Acid results in increased activity of NR1H4 protein | PMID:15821044 PMID:21543282 PMID:22561792 PMID:27871908 | Nr1h4 | increases expression | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Lithocholic Acid results in increased expression of NR1H4 mRNA | PMID:25055961 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; NR1H4 protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA] | PMID:19965603 PMID:21311750 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein; Lithocholic Acid binds to and results in decreased activity of NR1H4 protein; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; Lithocholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter] | PMID:14684751 PMID:15489543 PMID:15821044 PMID:17963371 PMID:18180267 PMID:21291553 PMID:22561792 PMID:25257666 | | ||||||||||||||||||||||
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