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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734104
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:10089
Term: Yangonin
Definition: A 2-pyranone that has formula C15H14O4.
Chemical ID: MESH:C110481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4affects response to substanceEXP 6480464CTDNR1H4 affects the susceptibility to yangoninPMID:29660435
Nr1h4increases expressionEXP 6480464CTDyangonin results in increased expression of NR1H4 mRNAPMID:29660435
Nr1h4multiple interactionsEXP 6480464CTDNR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR1H4 protein]PMID:29660435
Nr1h4multiple interactionsISONR1H4 (Homo sapiens)6480464CTDyangonin binds to and results in increased activity of NR1H4 proteinPMID:29660435
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