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GENE - TERM ANNOTATION REPORT

RGD ID: 734037
Species: Homo sapiens
RGD Object: Gene
Symbol: COL2A1
Name: collagen type II alpha 1 chain
Acc ID: GO:0062023
Term: collagen-containing extracellular matrix
Definition: An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
Definition Source(s): GOC:BHF, GOC:rph, PMID:21123617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL2A1 ISOCol2a1 (Rattus norvegicus)9068941RGD PMID:7649371 REF_RGD_ID:1298775
COL2A1located_inHDA 150520179BHF-UCL PMID:23658023 PMID:27559042 PMID:28327460 PMID:28344315 PMID:28675934

PMID:23658023 PMID:27559042 PMID:28327460 PMID:28344315 PMID:28675934
COL2A1located_inNAS 150520179ComplexPortal PMID:17876790

PMID:17876790
COL2A1is_active_inIBAFB:FBgn0000299 or FB:FBgn0016075 or MGI:104687 or MGI:104688 or MGI:1858212 or MGI:2152695 or MGI:2672118 or MGI:2685312 or MGI:88449 or MGI:88451 or MGI:88452 or MGI:88453 or MGI:88454 or MGI:88455 or MGI:88456 or MGI:88457 or MGI:88462 or MGI:88467 or MGI:88468 or PANTHER:PTN001166351 or Col11a1 (Rattus norvegicus) or Col2a1 (Rattus norvegicus) or Col5a3 (Rattus norvegicus) or Col3a1 (Rattus norvegicus) or UniProtKB:A0A0G2K7A5 or UniProtKB:P02452 or UniProtKB:P02458 or UniProtKB:P02460 or UniProtKB:P02461 or UniProtKB:P02462 or UniProtKB:P02467 or UniProtKB:P05997 or UniProtKB:P08123 or UniProtKB:P12107 or UniProtKB:P20908 or UniProtKB:P53420 or UniProtKB:Q01955 or UniProtKB:Q03692 or WB:WBGene00000527 or WB:WBGene00001263 or WB:WBGene00002280150520179GO_Central GO_REF:0000033
COL2A1located_inIEAPANTHER:PTHR24023:SF58150520179TreeGrafter GO_REF:0000118
COL2A1located_inIEAARBA:ARBA00028162150520179UniProt GO_REF:0000117
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