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GENE - TERM ANNOTATION REPORT

RGD ID: 733995
Species: Homo sapiens
RGD Object: Gene
Symbol: SIRT2
Name: sirtuin 2
Acc ID: DOID:3669
Term: intermittent claudication
Definition: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Definition Source(s): MESH:D007383
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIRT2 ISORGD:6214819586024RGDassociated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord 
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