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GENE - TERM ANNOTATION REPORT

RGD ID: 733994
Species: Mus musculus
RGD Object: Gene
Symbol: Tsc1
Name: TSC complex subunit 1
Acc ID: DOID:9002904
Term: Primitive Neuroectodermal Tumors
Definition: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Definition Source(s): MESH:D018242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tsc1 ISOTSC1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Primitive neuroectodermal tumorPMID:16554133 PMID:21309039 PMID:22703879 PMID:23514105 PMID:25077650 PMID:25498131 PMID:25722345 PMID:25741868 PMID:26467025 PMID:27153395 PMID:28492532 PMID:30076350 PMID:31054281
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