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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733969
Species: Mus musculus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of kappaB kinase beta
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbincreases expressionEXP 6480464CTDtitanium dioxide results in increased expression of IKBKB mRNA; titanium dioxide results in increased expression of IKBKB proteinPMID:28646487 PMID:29128614 PMID:29264374
Ikbkbmultiple interactionsEXP 6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IKBKB mRNAPMID:29950665
Ikbkbincreases expressionISOIKBKB (Homo sapiens)6480464CTDtitanium dioxide results in increased expression of IKBKB mRNAPMID:22342292
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