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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733927
Species: Mus musculus
RGD Object: Gene
Symbol: Vldlr
Name: very low density lipoprotein receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vldlraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of VLDLR mRNAPMID:21570461 PMID:26377647
Vldlrdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of VLDLR mRNAPMID:15034205
Vldlrincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of VLDLR mRNAPMID:16120747 PMID:16960034 PMID:18372398 PMID:19465110 PMID:19933214 PMID:26290441 PMID:28213091 PMID:28238261 PMID:28922406 PMID:32553695
Vldlrmultiple interactionsEXP 6480464CTDAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of VLDLR mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to VLDLR gene]PMID:15034205 PMID:28213091
Vldlraffects expressionISOVldlr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of VLDLR mRNAPMID:34747641
Vldlrdecreases expressionISOVLDLR (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of VLDLR mRNAPMID:11007951
Vldlrincreases expressionISOVldlr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of VLDLR mRNAPMID:33387578
Vldlrmultiple interactionsISOVLDLR (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of VLDLR mRNA; Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of VLDLR mRNA]PMID:11007951 PMID:29704546
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