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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733897
Species: Homo sapiens
RGD Object: Gene
Symbol: TH
Name: tyrosine hydroxylase
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THincreases expressionISOTh (Rattus norvegicus)6480464CTDNitroprusside results in increased expression of TH proteinPMID:12088752
THmultiple interactionsISOTh (Rattus norvegicus)6480464CTD[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein; Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]PMID:12088752 PMID:16023617
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