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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733897
Species: Homo sapiens
RGD Object: Gene
Symbol: TH
Name: tyrosine hydroxylase
Acc ID: CHEBI:18291
Term: manganese atom
Definition: A manganese group element atom that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THdecreases expressionISOTh (Rattus norvegicus)6480464CTDManganese results in decreased expression of TH mRNA; Manganese results in decreased expression of TH proteinPMID:16943606 PMID:19781568 PMID:20224926 PMID:20798247
THmultiple interactionsISOTh (Mus musculus)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein]PMID:34590183
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