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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:48607
Term: lithium chloride
Definition: A metal chloride salt with a Li(+) counterion.
Chemical ID: MESH:D018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases activityEXP 6480464CTDLithium Chloride results in decreased activity of GSK3B proteinPMID:15364539 PMID:15585669 PMID:19442631 PMID:20694829
Gsk3bincreases phosphorylationEXP 6480464CTDLithium Chloride results in increased phosphorylation of GSK3B proteinPMID:27018151
Gsk3bincreases stabilityEXP 6480464CTDLithium Chloride results in increased stability of GSK3B proteinPMID:19448134
Gsk3bmultiple interactionsEXP 6480464CTD[[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNA; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of AHR mRNA; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of AXIN2 mRNA; [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in decreased expression of SNAI1 protein; [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein; Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [perfluorooctane sulfonic acid results in decreased phosphorylation of GSK3B protein]; Lithium Chloride promotes the reaction [Cisplatin results in increased phosphorylation of GSK3B protein]; Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:19440036 PMID:19582394 PMID:21498875 PMID:27018151 PMID:27050422 PMID:30171970 PMID:31220555
Gsk3baffects phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDLithium Chloride affects the phosphorylation of GSK3B proteinPMID:21364661
Gsk3bdecreases activityISOGsk3b (Rattus norvegicus)6480464CTDLithium Chloride results in decreased activity of GSK3B proteinPMID:15247282 PMID:18972237
Gsk3bdecreases activityISOGSK3B (Homo sapiens)6480464CTDLithium Chloride results in decreased activity of GSK3B proteinPMID:19101580 PMID:19274078 PMID:19823589 PMID:22944069
Gsk3bdecreases expressionISOGsk3b (Rattus norvegicus)6480464CTDLithium Chloride results in decreased expression of GSK3B mRNAPMID:18932008
Gsk3bdecreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDLithium Chloride results in decreased phosphorylation of GSK3B proteinPMID:20093106
Gsk3bincreases expressionISOGSK3B (Homo sapiens)6480464CTDLithium Chloride results in increased expression of GSK3B protein modified formPMID:22944069 PMID:30703377
Gsk3bincreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDLithium Chloride results in increased phosphorylation of GSK3B proteinPMID:23651617 PMID:27658547 PMID:28759639 PMID:37075934
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDLithium Chloride results in increased phosphorylation of GSK3B proteinPMID:18830594 PMID:20696143 PMID:21278055
Gsk3bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTD[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein; [Lithium Chloride co-treated with Cisplatin] results in increased phosphorylation of GSK3B protein; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein; calyculin A promotes the reaction [Lithium Chloride results in increased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Lithium Chloride inhibits the reaction [Matrines results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [triptolide results in increased phosphorylation of GSK3B protein]; Lithium Chloride promotes the reaction [Cadmium results in increased phosphorylation of GSK3B protein]; Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:12813129 PMID:18972237 PMID:20807582 PMID:20937724 PMID:24464479 PMID:26459185 PMID:27658547 PMID:30926361 PMID:31220555 PMID:37075934
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of and results in increased phosphorylation of CTNNB1 protein; [Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of EGFR mRNA; [Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of EGFR protein; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 mRNA; [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of HSPA1A protein alternative form; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 mRNA; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 protein; CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]; GSK3B protein mutant form inhibits the reaction [Lithium Chloride results in decreased expression of and results in decreased activity of ACHE protein]; GSK3B protein mutant form inhibits the reaction [Lithium Chloride results in increased degradation of ACHE protein]; Lithium Chloride inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in decreased expression of GSK3B protein modified form]; Lithium Chloride inhibits the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of GSK3B protein]; Lithium Chloride inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Proanthocyanidins results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]; Lithium Chloride promotes the reaction [quinocetone affects the phosphorylation of and results in decreased activity of GSK3B protein]; Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein; Lithium Chloride results in decreased expression of and results in increased phosphorylation of GSK3B protein; Lithium Chloride results in increased expression of and results in increased phosphorylation of and results in decreased activity of GSK3B protein; Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein; PIK3CA protein affects the reaction [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein]PMID:15753396 PMID:17868649 PMID:19196980 PMID:19274078 PMID:19679347 PMID:20090934 PMID:21296133 PMID:22493441 PMID:22944069 PMID:26990689 PMID:28343033 PMID:28886972 PMID:30703377 PMID:31715269 PMID:32112862 PMID:35985571 PMID:37551626
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