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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDecitabine results in decreased expression of BNIP3 mRNA

PMID:15251184
multiple interactionsEXP 6480464CTD[Decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BNIP3 mRNA

PMID:15251184
affects expressionISORGD:13509136480464CTDDecitabine affects the expression of BNIP3 mRNA

PMID:23300844
decreases methylationISORGD:13509136480464CTDDecitabine results in decreased methylation of BNIP3 promoter

PMID:15942716, PMID:17195906
increases expressionISORGD:13509136480464CTDDecitabine results in increased expression of BNIP3 mRNA, Decitabine results in increased expression of BNIP3 protein

PMID:15942716, PMID:16367923, PMID:19732952
multiple interactionsISORGD:13509136480464CTD[Decitabine results in decreased methylation of BNIP3 promoter] which results in increased expression of BNIP3 mRNA

PMID:17195906
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.