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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCisplatin results in increased expression of BNIP3 mRNA

PMID:21074548
increases phosphorylationEXP 6480464CTDCisplatin results in increased phosphorylation of BNIP3 protein

PMID:22006019
affects expressionISORGD:13509136480464CTDCisplatin affects the expression of BNIP3 mRNA

PMID:23300844
decreases expressionISORGD:13509136480464CTDCisplatin results in decreased expression of BNIP3 mRNA

PMID:29690507
increases expressionISORGD:6208006480464CTDCisplatin results in increased expression of BNIP3 mRNA

PMID:21575413
multiple interactionsISORGD:13509136480464CTD[2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Cisplatin] results in decreased expression of BNIP3 mRNA, Oxygen deficiency inhibits the reaction [[2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Cisplatin] results in decreased expression of BNIP3 mRNA], Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of BNIP3 mRNA]

PMID:29690507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.