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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDOxygen deficiency affects the expression of BNIP3 mRNA

PMID:17193925
increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of BNIP3 mRNA

PMID:20880076, PMID:23624791
increases expressionISORGD:13509136480464CTDOxygen deficiency results in increased expression of BNIP3 mRNA, Oxygen deficiency results in increased expression of BNIP3 protein

PMID:17914565, PMID:20042640, PMID:24236059, PMID:25596134, PMID:26082309, PMID:27292261, PMID:29690507, PMID:30381462
increases expressionISORGD:6208006480464CTDOxygen deficiency results in increased expression of BNIP3 protein

PMID:29139225
multiple interactionsISORGD:13509136480464CTD[2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Oxygen deficiency] results in increased expression of BNIP3 mRNA, [Quinolones co-treated with Oxygen deficiency] results in increased expression of BNIP3 mRNA, Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 mRNA], Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein], Oxygen deficiency inhibits the reaction [[2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Cisplatin] results in decreased expression of BNIP3 mRNA], Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of BNIP3 mRNA], Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]]

PMID:26082309, PMID:29690507
multiple interactionsISORGD:6208006480464CTDTea inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]

PMID:29139225
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.