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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733802
Species: Mus musculus
RGD Object: Gene
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Acc ID: CHEBI:16336
Term: hyaluronic acid
Definition: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
Chemical ID: MESH:D006820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k1multiple interactionsEXP 6480464CTDHyaluronic Acid analog affects the localization of [MAP3K1 protein binds to CD44 protein]; Hyaluronic Acid analog promotes the reaction [MAP3K1 protein binds to CD44 protein]; Hyaluronic Acid analog results in increased phosphorylation of and results in increased activity of MAP3K1 proteinPMID:20159036
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