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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733729
Species: Homo sapiens
RGD Object: Gene
Symbol: MLH1
Name: mutL homolog 1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MLH1increases expressionISOMlh1 (Rattus norvegicus)6480464CTDFenofibrate results in increased expression of MLH1 mRNAPMID:17264098 PMID:18775883
MLH1multiple interactionsISOMlh1 (Rattus norvegicus)6480464CTD[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNAPMID:18253720 PMID:18775883
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