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GENE - TERM ANNOTATION REPORT

RGD ID: 733712
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF4
Name: activating transcription factor 4
Acc ID: GO:0036499
Term: PERK-mediated unfolded protein response
Definition: The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
Definition Source(s): GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF4involved_inIEAUniProtKB:Q06507 or ensembl:ENSMUSP00000105234150520179Ensembl GO_REF:0000107
ATF4involved_inTAS 150520179ParkinsonsUK-UCL PMID:22013210 PMID:22934019

PMID:22013210 PMID:22934019
ATF4involved_inISSUniProtKB:Q06507150520179UniProt GO_REF:0000024
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