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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733705
Species: Homo sapiens
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1affects localizationEXP 6480464CTDNiclosamide affects the localization of CTNNB1 proteinPMID:35115509
CTNNB1decreases activityEXP 6480464CTDNiclosamide results in decreased activity of CTNNB1 proteinPMID:25174399
CTNNB1decreases expressionEXP 6480464CTDNiclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 proteinPMID:21531761 PMID:24552774 PMID:24736023 PMID:27492973 PMID:28284560 PMID:30143678 PMID:36318118
CTNNB1increases expressionEXP 6480464CTDNiclosamide results in increased expression of CTNNB1 mRNAPMID:22576131
CTNNB1increases ubiquitinationEXP 6480464CTDNiclosamide results in increased ubiquitination of CTNNB1 proteinPMID:27492973
CTNNB1multiple interactionsEXP 6480464CTDCTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]; Niclosamide results in decreased expression of and results in increased phosphorylation of CTNNB1 proteinPMID:19772353 PMID:24534281 PMID:27492973 PMID:35115509
CTNNB1decreases expressionISOCtnnb1 (Mus musculus)6480464CTDNiclosamide results in decreased expression of CTNNB1 mRNAPMID:27226553
CTNNB1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTDNiclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]PMID:26964897 PMID:32961231
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