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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733705
Species: Homo sapiens
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1multiple interactionsEXP 6480464CTD[Arsenic co-treated with Estradiol] results in decreased expression of CTNNB1 mRNA; Estradiol inhibits the reaction [ESR1 protein promotes the reaction [BTRC protein binds to CTNNB1 protein]]; Estradiol promotes the reaction [CTNNB1 protein binds to ESR1 protein]; Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]; Estradiol results in increased expression of and affects the localization of CTNNB1 protein; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]PMID:16053526 PMID:26990689 PMID:27156127 PMID:33047385
CTNNB1affects localizationISOCtnnb1 (Rattus norvegicus)6480464CTDEstradiol affects the localization of CTNNB1 proteinPMID:17170212
CTNNB1increases expressionISOCtnnb1 (Mus musculus)6480464CTDEstradiol results in increased expression of CTNNB1 mRNAPMID:14648872
CTNNB1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTD[Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein; Estradiol results in increased expression of and affects the localization of CTNNB1 proteinPMID:11786374 PMID:23684557
CTNNB1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTD[Estradiol co-treated with bisphenol A] results in decreased expression of CTNNB1 mRNA; Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of CTNNB1 protein alternative form]; Estradiol promotes the reaction [CTNNB1 protein binds to LEF1 protein]PMID:17170212 PMID:27174447 PMID:30565903
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