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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733618
Species: Homo sapiens
RGD Object: Gene
Symbol: DNM1L
Name: dynamin 1 like
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNM1Laffects localizationEXP 6480464CTDRotenone affects the localization of DNM1L proteinPMID:30240821
DNM1Ldecreases expressionEXP 6480464CTDRotenone results in decreased expression of DNM1L mRNAPMID:30240821
DNM1Lincreases expressionEXP 6480464CTDRotenone results in increased expression of DNM1L mRNA; Rotenone results in increased expression of DNM1L proteinPMID:29183837 PMID:33512557 PMID:37156403
DNM1Lmultiple interactionsEXP 6480464CTD4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of DNM1L protein]; CSNK2A1 protein affects the reaction [Rotenone results in increased expression of DNM1L protein]; DNM1L protein affects the reaction [Rotenone affects the localization of PINK1 protein]; DNM1L protein affects the reaction [Rotenone affects the localization of PRKN protein]; Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]; PQQ Cofactor inhibits the reaction [Rotenone affects the localization of DNM1L protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of DNM1L mRNA]; Rotenone inhibits the reaction [evodiamine results in increased phosphorylation of DNM1L protein]; Rotenone results in increased expression of and results in increased phosphorylation of DNM1L proteinPMID:28071871 PMID:29183837 PMID:30240821 PMID:32001317 PMID:34808100 PMID:37156403
DNM1Laffects localizationISODnm1l (Rattus norvegicus)6480464CTDRotenone affects the localization of DNM1L proteinPMID:32088201
DNM1Ldecreases expressionISODnm1l (Rattus norvegicus)6480464CTDRotenone results in decreased expression of DNM1L mRNA; Rotenone results in decreased expression of DNM1L proteinPMID:26770656 PMID:30240821
DNM1Ldecreases expressionISODnm1l (Mus musculus)6480464CTDRotenone results in decreased expression of DNM1L mRNAPMID:23186747
DNM1Lincreases expressionISODnm1l (Rattus norvegicus)6480464CTDRotenone results in increased expression of DNM1L proteinPMID:28526446
DNM1Lmultiple interactionsISODnm1l (Rattus norvegicus)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Rotenone affects the localization of DNM1L protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of DNM1L mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of DNM1L mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of DNM1L protein]; thymoquinone inhibits the reaction [Rotenone results in increased expression of DNM1L protein]PMID:26770656 PMID:28526446 PMID:30240821 PMID:32088201
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