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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733604
Species: Mus musculus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoeincreases expressionEXP 6480464CTDSevoflurane results in increased expression of APOE mRNA; Sevoflurane results in increased expression of APOE mRNA alternative formPMID:35575159
Apoemultiple interactionsEXP 6480464CTDAPOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of MAP2 protein]; APOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of PHF1 protein]; APOE protein alternative form inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPT protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL1B protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL6 protein]; Sevoflurane affects the reaction [APOE protein affects the expression of TNF protein]; Sevoflurane results in increased expression of and results in increased degradation of APOE proteinPMID:35575159
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