GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | decreases expression | EXP | | 6480464 | CTD | fexofenadine results in decreased expression of APOE mRNA | PMID:24852568 | Apoe | multiple interactions | EXP | | 6480464 | CTD | [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of IL1A protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased abundance of Cholesterol, LDL; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of CCL3 protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA; APOE gene mutant form inhibits the reaction [fexofenadine results in decreased expression of MLXIPL mRNA]; APOE protein results in decreased susceptibility to [Dietary Fats co-treated with fexofenadine] | PMID:24852568 PMID:25020133 | | ||||||||||||||||||||||
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