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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733604
Species: Mus musculus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoemultiple interactionsEXP 6480464CTDAPOE gene polymorphism results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]PMID:31626305
Apoedecreases expressionISOApoe (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of APOE mRNAPMID:30185694
Apoeincreases methylationISOApoe (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of APOE promoterPMID:30185694
Apoemultiple interactionsISOApoe (Rattus norvegicus)6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of APOE mRNA; Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of APOE mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of APOE mRNA]; GW 3965 promotes the reaction [Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of APOE mRNA]]PMID:30185694 PMID:33188856
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