GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ADRB2 | affects expression | EXP | | 6480464 | CTD | Isoproterenol affects the expression of ADRB2 mRNA | PMID:24705868 | ADRB2 | increases activity | EXP | | 6480464 | CTD | Isoproterenol results in increased activity of ADRB2 protein | PMID:21629661 PMID:27825928 PMID:34601065 | ADRB2 | increases expression | EXP | | 6480464 | CTD | Isoproterenol results in increased expression of ADRB2 mRNA | PMID:19483313 | ADRB2 | increases phosphorylation | EXP | | 6480464 | CTD | Isoproterenol results in increased phosphorylation of ADRB2 protein | PMID:16980553 | ADRB2 | increases uptake | EXP | | 6480464 | CTD | Isoproterenol results in increased uptake of ADRB2 protein | PMID:17925438 | ADRB2 | multiple interactions | EXP | | 6480464 | CTD | 4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]; imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Isoproterenol binds to and results in increased activity of ADRB2 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein] | PMID:10226872 PMID:10516654 PMID:11752207 PMID:12920204 PMID:14730417 PMID:16036225 PMID:16980553 PMID:17196553 PMID:17925438 PMID:27825928 PMID:34601065 | ADRB2 | decreases expression | ISO | Adrb2 (Mus musculus) | 6480464 | CTD | Isoproterenol results in decreased expression of ADRB2; Isoproterenol results in decreased expression of ADRB2 mRNA | PMID:12963636 PMID:17350036 | ADRB2 | increases activity | ISO | Adrb2 (Mus musculus) | 6480464 | CTD | Isoproterenol results in increased activity of ADRB2 protein | PMID:18820136 PMID:21177286 PMID:9875846 | ADRB2 | increases activity | ISO | Adrb2 (Rattus norvegicus) | 6480464 | CTD | Isoproterenol results in increased activity of ADRB2 protein | PMID:11164953 | ADRB2 | multiple interactions | ISO | Adrb2 (Mus musculus) | 6480464 | CTD | [GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein; ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein] | PMID:15178407 PMID:18820136 PMID:9875846 | ADRB2 | multiple interactions | ISO | Adrb2 (Rattus norvegicus) | 6480464 | CTD | [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP] | PMID:11164953 PMID:18378355 | | ||||||||||||||||||||||
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