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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733541
Species: Mus musculus
RGD Object: Gene
Symbol: Egr2
Name: early growth response 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EGR2 mRNAPMID:21570461 PMID:24058054
Egr2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of EGR2 mRNAPMID:19770486
Egr2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of EGR2 mRNAPMID:16962184
Egr2affects expressionISOEGR2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of EGR2 mRNAPMID:22298810
Egr2affects methylationISOEGR2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the methylation of EGR2 5' UTR; Tetrachlorodibenzodioxin affects the methylation of EGR2 exon; Tetrachlorodibenzodioxin affects the methylation of EGR2 gene; Tetrachlorodibenzodioxin affects the methylation of EGR2 promoterPMID:28011154
Egr2decreases expressionISOEGR2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of EGR2 mRNAPMID:21296121
Egr2increases expressionISOEGR2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of EGR2 mRNAPMID:20106945 PMID:30096437
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