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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733529
Species: Mus musculus
RGD Object: Gene
Symbol: Keap1
Name: kelch-like ECH-associated protein 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1affects expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of KEAP1 mRNAPMID:31563530
Keap1decreases expressionISOKEAP1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KEAP1 proteinPMID:24709675
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased expression of KEAP1 protein]PMID:24709675
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