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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733529
Species: Mus musculus
RGD Object: Gene
Symbol: Keap1
Name: kelch-like ECH-associated protein 1
Acc ID: CHEBI:2665
Term: amitraz
Definition: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
Chemical ID: MESH:C014983
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1increases expressionISOKeap1 (Rattus norvegicus)6480464CTDamitraz results in increased expression of KEAP1 proteinPMID:31029719
Keap1multiple interactionsISOKeap1 (Rattus norvegicus)6480464CTDKEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]PMID:31029719
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