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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733440
Species: Homo sapiens
RGD Object: Gene
Symbol: BECN1
Name: beclin 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BECN1increases expressionEXP 6480464CTDSirolimus results in increased expression of BECN1 proteinPMID:27107786 PMID:28025121 PMID:28888487 PMID:32430275 PMID:32645460
BECN1multiple interactionsEXP 6480464CTD[Sirolimus co-treated with TNF protein] results in increased expression of BECN1 protein; Sirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of BECN1 protein]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]PMID:21410490 PMID:28025121 PMID:29518472 PMID:30555576 PMID:31676321 PMID:32306690
BECN1increases expressionISOBecn1 (Rattus norvegicus)6480464CTDSirolimus results in increased expression of BECN1 mRNA; Sirolimus results in increased expression of BECN1 proteinPMID:26648565 PMID:26825372 PMID:30611790 PMID:30629952
BECN1increases expressionISOBecn1 (Mus musculus)6480464CTDSirolimus results in increased expression of BECN1 proteinPMID:20358864 PMID:30905858 PMID:32430275 PMID:34536393
BECN1multiple interactionsISOBecn1 (Rattus norvegicus)6480464CTD[Sirolimus co-treated with cadmium acetate] results in increased expression of BECN1 mRNA; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]PMID:29505745 PMID:29518472 PMID:29870746 PMID:30629952 PMID:33823232 PMID:35134463
BECN1multiple interactionsISOBecn1 (Mus musculus)6480464CTDSirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [phenanthrene results in decreased expression of BECN1 mRNA]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [Trichloroethylene results in increased expression of BECN1 protein]PMID:33823232 PMID:34453960 PMID:35134463 PMID:36849104
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