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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733398
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh1a3
Name: aldehyde dehydrogenase family 1, subfamily A3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of RALDH3 mRNAPMID:34363983
Aldh1a3increases response to substanceEXP 6480464CTDALDH1A3 results in increased susceptibility to TetrachlorodibenzodioxinPMID:21807577
Aldh1a3affects expressionISOAldh1a3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of ALDH1A3 mRNAPMID:32109520
Aldh1a3increases expressionISOALDH1A3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ALDH1A3 mRNAPMID:12377990 PMID:15345368 PMID:17968679 PMID:19619570 PMID:19684285 PMID:22903824 PMID:29704546
Aldh1a3multiple interactionsISOALDH1A3 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNA; [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ALDH1A3 mRNA; [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH1A3 mRNA]PMID:14761676 PMID:19619570 PMID:19684285 PMID:29704546
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